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Friday, July 31, 2020 | History

2 edition of effect of training on beta adrenergic receptor number in rat heart found in the catalog.

effect of training on beta adrenergic receptor number in rat heart

Russell Lewis Moore

effect of training on beta adrenergic receptor number in rat heart

by Russell Lewis Moore

  • 285 Want to read
  • 3 Currently reading

Published .
Written in English

    Subjects:
  • Adrenergic beta blockers.,
  • Rats -- Physiology.

  • Edition Notes

    Statementby Russell Lewis Moore.
    The Physical Object
    Paginationviii, 37 leaves, bound :
    Number of Pages37
    ID Numbers
    Open LibraryOL16536793M

    adrenergic signaling is impaired in hypertensive cardiomyocytes via GRK2 (red arrows). Exercise training attenuates GRK2 and calcineurin abundance in hypertension (green arrows) thereby allowing greater phosphorylation of PKA targets (green +) such as phospholamban (PLB), ryanodine receptor (RyR), and the L-type channel leading to improved systolic and diastolic functions during stress and. Propranolol competitively antagonizes beta-adrenergic receptors, thereby causing negative chronotropic and inotropic effects leading to a reduction in cardiac output. NCI Thesaurus (NCIt) Propranolol is a nonselective beta-adrenergic receptor blocker (beta-blocker) that is widely used for the therapy of hypertension, cardiac arrhythmias, angina.

    @article{osti_, title = {Quantitative autoradiographic analysis of /sup /I-pindolol binding in Fischer rat brain: changes in beta-adrenergic receptor density with aging}, author = {Miller, J A and Zahniser, N R}, abstractNote = {Age-related changes in beta-adrenergic receptor density in Fischer rat brain were examined using in vitro /sup /I-pindolol (IPIN) binding and. Journal of Cardiovascular Pharmacology Publication Venue For.

    Effect of an exercise run to exhaustion on cAMP in the rat heart. J Appl Physiol –, Link Effect of training on β-adrenergic receptor number in rat heart. J Appl Physiol –, Beta-adrenergic receptor-G protein-adenylyl cyclase signal transduction in the failing heart. The effect of age on the density and the affinity of beta adrenergic receptors was determined in the hearts of Fischer rats at three ages, 6, 12, and 24 months old.


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Effect of training on beta adrenergic receptor number in rat heart by Russell Lewis Moore Download PDF EPUB FB2

Effect of training on beta-adrenergic receptor number in rat heart. Moore RL, Riedy M, Gollnick PD. Female Sprague-Dawley rats were subjected to endurance-training programs, and the effect of training on myocardial beta-adrenergic receptor number, receptor-binding characteristics, and adenylate cyclase (AC) activities associated with the Cited by:   The effects of physical training on beta-adrenergic receptors were evaluated in heart ventricular tissue of diabetic rats.

Mild diabetes mellitus was induced in rats with streptozotocin (45 mg/kg, iv). They were then submitted to a progressive week running programme on a treadmill.

Binding studies were done at six different concentrations of (−) [3H] dihydroalprenolol ( to nM Cited by:   SUMMARY. A diminished sympathetic activity has been related to training bradycardia seen at rest and during exercise.

In order to evaluate if changes in heart adrenergic receptors can be one of the mechanisms by which the sympathetic responsiveness could be decreased by physical training, the number and affinity of β-adrenergic receptors were determined in heart ventricular Cited by: In order to evaluate if changes in heart adrenergic receptors can be one of the mechanisms by which the sympathetic responsiveness could be decreased by physical training, the number and affinity of beta-adrenergic receptors were determined in heart ventricular tissue of rats submitted to a week running by: In addition, the beta-receptor population is not static, and during long-term therapy with beta-adrenergic blocking agents the number of receptors is increased.

The heart contains beta-1 and betaadrenergic receptors in the proportion In heart failure, cardiac beta-1 receptors are reduced in number and population. The processes involved in homologous desensitization and downregulation have been extensively investigated for the beta-2 adrenergic receptor.

The other adrenergic receptors, as well as many other G-protein-coupled receptors, appear to behave in a similar manner. Initial uncoupling of the beta-2 receptor from the G protein after agonist binding. This phenomenon termed tachyphylaxis is intimately related to the physiologic regulation of the adrenergic receptors.

A plausible explanation for the attenuating influence of the agonists on their own effect is a reversible decrease of the active receptor number resulting from modulation of receptor affinity or receptor responsiveness or both. [79] Barbier J, Rannou-Bekono F, Marchais J, Berthon P-M, Delamarche P, et al.

Effect of training on beta1 beta2 beta3 adrenergic and M2 muscarinic receptors in rat heart. Med Sci Sports Exerc. ; – Summary.

Primary mycolardial cell cultures and freshly isolated cardiac cells in suspension resprensent two isolated, whole cell models for investigating cellular transsarcolemmal 45 Ca ++ exchange in response to a receptor-coupled stimulus. Studies were performed to characterize beta-adrenergic receptor binding, beta-adrenergic receptor mediated cellular calcium (45 Ca ++) exchange, and.

A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.

Proc Natl Acad Sci USA. ; – [PMC free article]. Crude myocardial sarcolemmal membrane fractions were prepared from rat hearts subjected to total global ischemia with and without normoxic reperfusion, or global anoxic (N2) perfusion with and without normoxic reperfusion.

The direct effects on β-adrenenoceptor number, G-protein levels and stimulation of the adenylate cyclase (AC) complex were assessed.

In terms of AC activation, ischemia led. The beta-adrenergic antagonists CGP A (beta 1-selective) and ICI(beta 2-selective) blocked in a dose-dependent fashion the ability of isoproterenol to effect receptor mRNA levels.

The effects of different physical training regimes on the plasma catecholamine values at rest and the density and responsiveness of adrenergic receptors at rest were investigated. The changes during well-defined training periods of swimmers, long-distance runners, weight lifters and wrestlers were compared with untrained male volunteers.

The training of swimmers and long-distance runners. Epinephrine is a catecholamine, a sympathomimetic monoamine derived from the amino acids phenylalanine and is the active sympathomimetic hormone secreted from the adrenal medulla in most species.

It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral. β-adrenergic signaling in the heart at molecular level. For the first time the existence of β-adrenergic receptors (β-AR) was described in by Alquist ().At the present three subtypes of β-AR: β 1-AR, β 2-AR, β 3-AR have been recognized.A fourth subtype has been proposed and investigations have been recently clarified its functioning and localization (Lewis et al., ).

Surgery can correct tetralogy of Fallot, a form of congenital heart disease; however, patients risk cardiac complications and morbidity as adults. Liu et al. found decreased cardiomyocyte cell division in pediatric patients, suggesting that a reduction in endowment (number of cells) could contribute to adult-onset cardiac dysfunction.

In mouse models, inactivating the β-adrenergic receptor. The anti‐arrhythmic effects of beta‐blockers are mainly related to their capacity to inhibit beta‐receptor‐mediated adrenergic neural activation. The ability of the beta‐blockers to slow conduction and increase atrioventricular node refractoriness is useful in the prevention and treatment of supraventricular arrhythmias [ 46 ].

Lawrence Kwon, Clive Rosendorff, in Chronic Coronary Artery Disease, Introduction. β-Adrenergic receptors are G-protein coupled transmembrane proteins. Their main antianginal action lies in the intracellular part of the β-receptor that is coupled to the G-protein complex: G s (stimulatory) and G i (inhibitory).

Agonists bind to the ligand site and stimulate the β-adrenergic receptors. Ciaraldi, T., Marinetti, G.V.: Thyroxine and propylthiouracil effects in vivo on alpha and beta adrenergic receptors in rat heart.

Biochem. Biophys. Res. Commun. Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of | Explore the latest full-text research PDFs.

Exposure to chronic hypoxia results in a lower resting heart rate and a blunted cardiovascular responsiveness to beta-adrenergic receptor stimulation.

Possible effects of acclimatization to high altitude on the binding of [I]iodohydroxybenzylpindolol to beta-adrenergic receptors on membranes of right and left ventricles of rat heart were.β-adrenergic receptor (β-AR) agonists are among the most potent factors regulating cardiac electrophysiological properties.

Connexin 43 (Cx43), the predominant gap-junction protein in the [email protected]{osti_, title = {Development of adrenergic receptor binding sites in brain regions of the neonatal rat: effects of prenatal or postnatal exposure to methylmercury}, author = {Bartolome, J.V. and Kavlock, R.J. and Cowdery, T.

and Orband-Miller, L. and Slotkin, T.A.}, abstractNote = {In order to understand the effects of developmental exposure to methylmercury on the ontogeny of.